When did the first war between Whites and Indians occur?

The correct answer is 1637, which refers to the Pequot War. This conflict marked one of the first significant armed confrontations between English colonists and Native American tribes in North America. The war was primarily driven by territorial disputes and economic competition, as the Pequot tribe resisted the encroachment of English settlers in Connecticut. The Pequot War is notable for its brutality and high casualty rates among Native Americans, as well as for establishing patterns of conflict between European settlers and Indigenous peoples that would recur in subsequent years.

Other years listed do not correspond with the beginning of significant conflicts of this nature. For example, 1620 marks the arrival of the Pilgrims at Plymouth, establishing a settlement that would lead to later tensions, but no significant warfare occurred at that time. The year 1642 and 1650 also fall outside the timeline of the Pequot War and do not represent the earliest organized military engagements between Europeans and Native Americans, making them less relevant in the context of the question.